Ambient temperature and genome-wide DNA methylation: A twin and family study in Australia

R Xu; S Li; S Li; EM Wong; MC Southey; JL Hopper; MJ Abramson; Y Guo

Journal article

Ambient temperature and genome-wide DNA methylation: A twin and family study in Australia

R Xu, S Li, S Li, EM Wong, MC Southey, JL Hopper, MJ Abramson, Y Guo

Environmental Pollution | ELSEVIER SCI LTD | Published : 2021

DOI: 10.1016/j.envpol.2021.117700

Abstract

Little is known about the association between ambient temperature and DNA methylation, which is a potential biological process through which ambient temperature affects health. This study aimed to evaluate the association between ambient temperature and DNA methylation across human genome. We included 479 Australian women, including 132 twin pairs and 215 sisters of these twins. Blood-derived DNA methylation was measured using the HumanMethylation450 BeadChip array. Data on average ambient temperature during eight different exposure windows [lag0d (the blood draw day), lag0-7d (the current day and previous seven days prior to blood draw), lag0-14d, lag0-21d, lag0-28d, lag0-90d, lag0-180d, an..

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University of Melbourne Researchers

Shuai Li Author

Melissa Southey Author

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Grants

Awarded by Boehringer Ingelheim

Funding Acknowledgements

This work was supported by the China Scholarship Council [grant number 201806010405]; the Australian National Health and Medical Research Council [grant numbers APP1163693, APP1109193, APP1155163, APP1050561 and APP1079102]; the Victorian Cancer Agency (grant number ECRF 19020); and the Cancer Australia and National Breast Cancer Foundation [grant number 509307].